N?Heterocyclic Carbene?Catalyzed Atroposelective Annulation for Access to Thiazine Derivatives with C?N Axial Chirality
نویسندگان
چکیده
A catalytic atroposelective cycloaddition reaction between thioureas and ynals is developed. This features the first NHC-catalyzed addition of to acetylenic acylazolium intermediates eventually set up C?N axial chirality with excellent optical purities. The obtained axially chiral thiazine derivative products bear multiple functional groups are feasible for further transformations.
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2021
ISSN: ['1521-3773', '1433-7851', '0570-0833']
DOI: https://doi.org/10.1002/anie.202010606